We don't make claims. We cite trials.

We don't describe how a supplement feels. We point to peer reviewed, placebo controlled human trials of KSM-66® and let you read them. Every number here links to its PubMed source.

50+
Clinical studies
600mg
Studied dose
p<.0001
Cortisol vs. placebo
Study 01 · Chandrasekhar 2012
−27.9%

Serum cortisol reduction over 60 days in adults with chronic stress, versus placebo. Randomized, double blind.

PubMed 23439798 →
Figure 1 · Serum cortisol over 60 days PubMed 23439798 →

Cortisol fell 27.9% over 60 days.

100%94%88%82%76%72% Day 0D20D40D50D60 −27.9%
KSM-66® 600 mg (n=32)Placebo (n=32)

The trial behind the headline number.

Participants
64 adults
Population
Chronic stress
Daily dose
600 mg KSM-66®
Duration
60 days
Design
RCT · double blind
Journal
Indian J Psychol Med

Three more results we keep coming back to.

Study 02 · Stress · Salve 2019

Significant reduction in perceived stress.

PSS scores at baselineHigh
PSS scores at 8 weeksSignificantly reduced

KSM-66® at 600 mg/day significantly improved Perceived Stress Scale scores over 8 weeks in a randomized, double blind, placebo controlled trial.

PubMed 32021735 →
Study 03 · Sleep · Langade 2019

Faster onset, deeper sleep.

Sleep onset latency−39%
Total sleep time+23%
Sleep efficiency+21%

10 weeks, n=80. Onset latency fell 39%; total sleep time rose 23%.

PubMed 31728244 →
Study 04 · Performance · Choudhary 2015
+13%

VO2max in elite cyclists.

Aerobic capacity rose 13% after 8 weeks. Placebo group: +1.8%.

PubMed 26730141 →

50+ clinical studies. Key trials in chronological order.

2012Chandrasekhar et al.Indian J Psychol MedSafety and efficacy of a high concentration full spectrum extract on chronic stress.PMID →
2015Choudhary et al.AYUEffect on cardiorespiratory endurance in elite cyclists.PMID →
2015Wankhede et al.J Int Soc Sports NutrEffect on muscle mass and strength in healthy young men.PMID →
2017Pingali et al.Pharmacognosy ResCognitive and memory enhancement effects.PMID →
2019Langade et al.CureusEfficacy and safety in insomnia: a prospective study.PMID →
2019Salve et al.CureusAdaptogenic and anxiolytic effect in healthy adults.PMID →
2019Lopresti et al.MedicineInvestigation into stress relieving and pharmacological actions.PMID →
2020Kelgane et al.CureusAnti anxiety effect in the elderly: 8 week randomized trial.PMID →
2021Gopukumar et al.Evid Based Compl Alt MedEfficacy and safety on stress and improvement in cognition.PMID →

+ 15 additional trials available on request · updated quarterly.

The trial dose, dosed to the trial.

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