Peer-Reviewed Research

The Science Behind Optibio

Every ingredient is clinically studied. Every claim is backed by peer-reviewed research. No proprietary blends, no hidden dosages — just transparent, evidence-based formulation.

🔬 24+ Clinical Trials
📊 Peer-Reviewed Journals
🛡️ Third-Party Verified
🇺🇸 FDA-Audited Facility

Our Ingredient

We use only clinically studied, patented ingredients at their researched dosages. No proprietary blends, no pixie-dusting.

★ Patented Ingredient

KSM-66® Ashwagandha

KSM-66® is the world's most clinically studied ashwagandha extract — a full-spectrum root extract standardized to 5% withanolides. Unlike generic ashwagandha products that use leaf or aerial parts, KSM-66® uses only the root, preserving the natural balance of active compounds exactly as studied in clinical trials.

The patented milk-based extraction process — developed over 14 years of R&D — maintains the natural ratio of withanolides without harsh chemical solvents, producing the most bioavailable form of ashwagandha available.

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Full-Spectrum Root Extract
Uses only the root — not leaf or aerial parts — preserving the complete natural compound profile as studied in clinical trials.
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Milk-Based Extraction
Patented 14-year process that maintains the natural ratio of active compounds without harsh chemical solvents.
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Clinical Dosage: 600mg
The exact dosage used in clinical trials. Not an underdosed 'sprinkle' like many competitors — 50% more capsules per bottle.
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24+ Gold-Standard Studies
The most clinically studied ashwagandha extract in the world, with randomized, double-blind, placebo-controlled trials.

📋 Supplement Facts

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600mg Per Serving
2 Capsules / Serving
45 Servings / Bottle
5% Withanolides

Clinical Studies

Real outcomes from peer-reviewed, placebo-controlled clinical trials using KSM-66® ashwagandha at 600mg/day.

Randomized, Double-Blind, Placebo-Controlled
27.9% Cortisol Reduction
Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety
📰 Indian J Psychol Med 📅 2012 👥 64 adults ⏱ 60 days

Adults with chronic stress receiving 600mg/day KSM-66® showed a 27.9% reduction in serum cortisol and significant improvements on all stress-assessment scales compared to placebo.

View on PubMed →
Randomized, Double-Blind, Placebo-Controlled
Sleep Efficiency: 75.6% → 83.5%
Efficacy and Safety of Ashwagandha Root Extract on Sleep Quality in Insomnia and Anxiety
📰 Cureus 📅 2019 👥 60 adults ⏱ 10 weeks

Participants taking 600mg/day KSM-66® showed significant improvement in sleep quality, with sleep efficiency improving from 75.6% to 83.5% — a clinically meaningful change.

View on PubMed →
Randomized, Double-Blind, Placebo-Controlled
44% Stress Reduction (PSS)
Body Weight Management in Adults Under Chronic Stress Through Ashwagandha Root Extract
📰 J Evid Based Complement Altern Med 📅 2015 👥 52 adults ⏱ 8 weeks

Chronically stressed adults receiving KSM-66® showed a 44% reduction in perceived stress (PSS score) and significant improvements in food cravings and reactive eating.

View on PubMed →
Randomized, Double-Blind, Placebo-Controlled
13% VO2max Improvement
Examining the Effect of Withania Somnifera on Muscle Strength and Recovery
📰 J Int Soc Sports Nutr 📅 2015 👥 57 adults ⏱ 8 weeks

Healthy men receiving 600mg/day KSM-66® showed significantly greater increases in muscle strength, muscle size, and cardiorespiratory endurance (VO2max) vs. placebo.

View on PubMed →
⚠️ These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.

Quality & Testing

Every batch undergoes rigorous testing before it reaches you. No shortcuts, no exceptions.

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Heavy Metal Testing

Screened for lead, mercury, cadmium, and arsenic — verified to be well below FDA safety limits.

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Microbial Testing

Tested for yeast, mold, E. coli, salmonella, and staph to ensure product safety and purity.

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Potency Verification

Confirmed to contain exactly 600mg KSM-66® with 5% withanolides — what's on the label is in the bottle.

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Identity Testing

Raw materials verified to be genuine KSM-66® ashwagandha root — not a substitute or adulterated material.

Our 5-Step Quality Assurance Process

1
Raw Material
Identity Testing
2
Potency &
Purity Analysis
3
Heavy Metal
Screening
4
Microbial
Testing
5
Third-Party
Verification

Sourcing & Traceability

We trace every ingredient from source to shelf. Full transparency, nothing to hide.

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KSM-66® by Ixoreal Biomed

Our ashwagandha is sourced from Ixoreal Biomed, the creators of KSM-66® — with over 24 gold-standard clinical trials and 14 years of R&D behind the extraction process.

Origin: Rajasthan, India — sustainably farmed
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FDA-Audited Manufacturing

Manufactured at an FDA-audited, cGMP-certified facility in the United States. Every step of production meets pharmaceutical-grade standards.

USA-based facility
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Independent Lab Testing

Every batch is sent to independent, third-party laboratories for comprehensive testing — heavy metals, microbial, potency, and identity verification.

Results available via Verify Your Batch
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Seed to Shelf Traceability

Every bottle is traceable from raw material sourcing to your doorstep. Purchase verification gives you access to your batch's full quality documentation.

COA and lab results available per batch

Ready to Feel the Difference?

Try Optibio risk-free with our 90-day money-back guarantee. If you don't feel calmer, sleep better, and think more clearly — we'll refund every penny.

Try Optibio Risk-Free
90-day money-back guarantee Free shipping on $75+ Third-party tested